Identification of the immunodominant regions of the melanoma antigen tyrosinase by anti-tyrosinase monoclonal antibodies
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Melanocyte differentiation Ags, including tyrosinase-related protein (TRP) 1, are relevant to both autoimmune skin depigmentation (vitiligo) and tumor immunity, because they are expressed by both benign melanocytes and many malignant melanomas. Melanoma patients generate CD4 + T cells that specifically recognize these proteins. TRP1 contains internal disulfide bonds and is presented by MHC clas...
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Recently, major advances have been made in the identification of antigens from human melanoma which are recognized by T cells. In spite of this, little is known about the optimal ways to use these antigens to treat patients with cancer. Progress in this area is likely to require accurate preclinical animal models, but the availability of such models has lagged behind developments in human tumor...
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ژورنال
عنوان ژورنال: Melanoma Research
سال: 2003
ISSN: 0960-8931
DOI: 10.1097/00008390-200310000-00006